Bile‐duct destruction and collagen deposition: A prominent ultrastructural feature of the liver in cystic fibrosis
Hepatology, ISSN: 1527-3350, Vol: 16, Issue: 2, Page: 372-381
1992
- 94Citations
- 18Captures
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Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
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Metrics Details
- Citations94
- Citation Indexes93
- 93
- CrossRef90
- Clinical Citations1
- PubMed Guidelines1
- Captures18
- Readers18
- 18
Article Description
To study the liver disease of patients with cystic fibrosis, percutaneous liver biopsies were performed in 10 patients with cystic fibrosis aged 6 to 22 yr. Nine of 10 patients had high Shwachman scores, eight had normal serum levels of transaminases. Lightmicroscopical examination showed steatosis in seven cases and in five slight or moderate inflammatory infiltration. Eight patients showed varying degrees of fibrosis and even cirrhosis. Six patients had bile‐duct proliferation and, in one case a bile plug was found. Other signs of cholestasis were not seen. Electron‐microscopical investigation showed no specific signs of cholestasis such as ductal plugs or intracellular bile pigments. The canaliculi were not dilated, except in one case. Most patients had bile‐duct cells with irregular shapes, protruding into the lumen, and some cases even had necrotic cells. Around the bile ducts and ductules, collagen was deposited and fatstoring cells were a common finding. Our findings do not support the view that cholestasis is the pathogenetic factor in liver disease in cystic fibrosis. A cytotoxic influence on the biliary cells, stimulating collagen deposition, seems more likely. (HEPATOLOGY 1992;16:372–381.) Copyright © 1992 American Association for the Study of Liver Diseases
Bibliographic Details
http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=0026688954&origin=inward; http://dx.doi.org/10.1002/hep.1840160215; http://www.ncbi.nlm.nih.gov/pubmed/1639346; https://journals.lww.com/01515467-199208000-00014; https://dx.doi.org/10.1002/hep.1840160215; https://aasldpubs.onlinelibrary.wiley.com/doi/10.1002/hep.1840160215
Ovid Technologies (Wolters Kluwer Health)
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