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Facile synthesis of aryl-pyridyl, pyridazinyl, pyrazinyl, and triazinyl acetonitriles

Journal of Heterocyclic Chemistry, ISSN: 0022-152X, Vol: 50, Issue: 3, Page: 585-589
2013
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Article Description

Dihalo pyridine, pyrazine, and pyridazine analogues were converted to the corresponding monohalo acetonitrile analogues through nucleophilic displacement of the halogen with the anion of tert-butyl cyanoacetate. The monohalo acetonitriles reacted under Suzuki or Stille conditions to form the title compounds. © 2013 HeteroCorporation.

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