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Conservation of the Polyamines Pathway in Ustilaginomycetes A Genomic and Experimental Approach

Journal of Basic Microbiology, ISSN: 1521-4028, Page: e2400561
2024
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  • Captures
    1
  • Mentions
    1
    • News Mentions
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Reports from Center for Scientific Research and Higher Education Ensenada Add New Data to Findings in Chemicals and Chemistry (Conservation of the Polyamines Pathway In Ustilaginomycetes a Genomic and Experimental Approach)

2024 DEC 09 (NewsRx) -- By a News Reporter-Staff News Editor at Chemicals & Chemistry Daily Daily -- Data detailed on Chemicals and Chemistry have

Article Description

Polyamines are organic and aliphatic molecules essential for the growth, development, and survival of both eukaryotes and prokaryotes. In fungi, polyamines play a crucial role in cellular differentiation and pathogenesis. Since fungi and animals are closely related evolutionarily, and fungi can be easily genetically manipulated in the lab, they serve as excellent models for studying polyamine metabolism and the molecular mechanisms controlled by these biomolecules. Although the metabolism of polyamines has been extensively studied in model fungi such as Saccharomyces cerevisiae and Ustilago maydis, the conservation of the polyamine biosynthesis pathway in other Ustilaginomycetes, a class of fungi that includes phytopathogens, saprophytes, mutualists, and mycorrhizae, has not been thoroughly investigated. In this study, using a genomic and bioinformatics approach, we analyzed the conservation of the polyamine biosynthesis pathway in Ustilaginomycetes. Additionally, we confirmed the functional conservation of ornithine decarboxylase (Odc), which is involved in the synthesis of putrescine, one of the most important polyamines in fungi and complex multicellular eukaryotic organisms, using genetics and molecular biology tools. Moreover, we identified the differentially regulated genes by this polyamine in U. maydis. This research provides insights into the similarities and differences in the conservation of the polyamine biosynthesis pathway in fungi, and it expands our understanding of the role of polyamines and the mechanisms regulated by these molecules in eukaryotes.

Bibliographic Details

Martínez-Soto, Domingo; Hernández-Rojas, Albo J; Valdés-Santiago, Laura; García-Ortega, Luis F; Ramírez-Martínez, Adriana; Trujillo-Esquivel, Elías; Pérez-Rodríguez, Fernando; Ortiz-Castellanos, Lucila; León-Ramírez, Claudia G; Esquivel-Naranjo, Edgardo Ulises; Ruiz-Herrera, José; Cervantes-Chávez, José Antonio

Wiley

Immunology and Microbiology

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