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Molecular adsorbent recirculating systems in patients with early allograft dysfunction after liver transplantation: A pilot study

Liver Transplantation, ISSN: 1527-6465, Vol: 12, Issue: 9, Page: 1357-1364
2006
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Article Description

Early allograft dysfunction (EAD) after orthotopic liver transplantation (OLT) causes marked morbidity and mortality. We conducted a prospective pilot study to assess the safety and efficacy of molecular adsorbent recirculating system (MARS) in treatment of EAD after OLT. Twelve consecutive adult liver allograft recipients with a median age of 48 years, 9 of whom were male, were prospectively included and supported with MARS. EAD was defined as the presence of at least 2 of the following: serum bilirubin >10 mg/dL, prothrombin time <40%, aspartate aminotransferase or alanine transferase >1,000 U/L, and plasma disappearance rate of indocyanine green (PDR) <10% per minute within 72 hours after reperfusion. One-year patient and graft survival was 66%. There was a significant decrease in serum bilirubin (P = 0.002), serum creatinine (P = 0.006), and aspartate aminotransferase (P = 0.005) and a significant increase in PDR (P = 0.007) after MARS treatment. Prothrombin time, albumin level, and platelet count remained stable. Sustained improvement of renal and neurological function and of mean arterial pressure were observed. No MARS-related adverse effects occurred. MARS treatment provides a safe approach to the treatment of EAD after OLT. On the basis of this pilot study, a multicenter randomized clinical trial that uses MARS treatment in EAD after OLT has been initiated. © 2006 AASLD.

Bibliographic Details

Hetz, Hubert; Faybik, Peter; Berlakovich, Gabriela; Baker, Amir; Bacher, Andreas; Burghuber, Christopher; Sandner, Sigrid E; Steltzer, Heinz; Krenn, Claus Georg

Ovid Technologies (Wolters Kluwer Health)

Medicine

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