No increase in blood transfusions during liver transplantation since the withdrawal of aprotinin
Liver Transplantation, ISSN: 1527-6473, Vol: 20, Issue: 5, Page: 584-590
2014
- 33Citations
- 32Captures
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Metrics Details
- Citations33
- Citation Indexes33
- CrossRef33
- 32
- Captures32
- Readers32
- 32
Conference Paper Description
The aims of this study were to determine whether the withdrawal of aprotinin (APRO) led to an increased bleeding risk in patients undergoing orthotopic liver transplantation (OLT). A retrospective analysis compared consecutive patients undergoing OLT and treated with aprotinin (APRO group; n = 100) with a group in which aprotinin was not used (no-APRO group; n = 100). Propensity score matching was then performed for each group to identify 2 matched cohorts. Patients were matched by their primary diagnoses and Model for End-Stage Liver Disease scores. This resulted in 2 matched cohorts with 55 patients in each group. None of the patients in the APRO group had significant fibrinolysis. In the no-APRO group, 23.6% of the patients developed fibrinolysis (P < 0.003). Tranexamic acid was used in 61.5% of the patients (n = 8) in the no-APRO group in whom lysis was present, and this resolved the fibrinolysis in all but 1 of these patients. There were no differences in red blood cell, fresh frozen plasma, platelet concentrate, or cryoprecipitate transfusions between the 2 groups. In conclusion, we have shown a significant increase in the prevalence of fibrinolysis during OLT since the withdrawal of APRO. However, there has been no increase in transfusion requirements. © 2014 American Association for the Study of Liver Diseases.
Bibliographic Details
http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84899522808&origin=inward; http://dx.doi.org/10.1002/lt.23839; http://www.ncbi.nlm.nih.gov/pubmed/24481770; https://journals.lww.com/01445473-201405000-00011; https://dx.doi.org/10.1002/lt.23839; https://aasldpubs.onlinelibrary.wiley.com/doi/full/10.1002/lt.23839
Ovid Technologies (Wolters Kluwer Health)
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