Metastatic endocrine tumors: Is there a place for liver transplantation?
Liver Transplantation and Surgery, ISSN: 1527-6473, Vol: 1, Issue: 2, Page: 111-117
1995
- 43Citations
- 17Captures
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Metrics Details
- Citations43
- Citation Indexes37
- 37
- CrossRef25
- Clinical Citations3
- PubMed Guidelines3
- Policy Citations3
- Policy Citation3
- Captures17
- Readers17
- 17
Article Description
The authors describe their experience with liver transplantation (OLT) for metastatic endocrine tumors (MET) in order to determine reasonable indications for OLT in patients with this disease. Removal of the primary lesion and subsequent liver transplantation were performed in two separate procedures in all patients except one. Only those patients suffering from objective tumor progression and symptoms with no evidence of extrahepatic spread after complete work‐up (including endoscopic ultrasonography (US) and I‐labeled Tyr‐octreotide body scanning) underwent liver transplantation. Fifteen patients were referred for liver transplantation. Seven patients were excluded either because of stability of liver metastases (n = 3), extrahepatic spread, general contraindication (n = 2), or feasibility of aggressive surgical resection (n = 2). Liver transplantation was undertaken in eight patients with carcinoid tumor (n = 4), gastrinoma (n = 3) and glucagonoma (n = 1). Three patients did not survive the surgical procedure itself, whereas two additional patients died from chronic rejection or from recurrent disease. Three patients who received transplants for metastatic carcinoid tumor are alive without biochemical or imaging evidence of disease recurrence at 6, 15, and 52 months. The best indication for transplantation seems to be patients with metastases restricted to the liver and unresponsive to adjuvant therapy after aggressive surgical resection including excision of the primary lesion and reduction of hepatic metastases. In such highly‐selected patients, liver transplantation remains a high‐risk operation, but it can yield long‐term survival Copyright © 1995 by the American Association for the Study of Liver Diseases. Copyright © 1995 American Association for the Study of Liver Diseases
Bibliographic Details
http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=0029258103&origin=inward; http://dx.doi.org/10.1002/lt.500010208; http://www.ncbi.nlm.nih.gov/pubmed/9346551; https://onlinelibrary.wiley.com/doi/10.1002/lt.500010208; https://dx.doi.org/10.1002/lt.500010208; https://aasldpubs.onlinelibrary.wiley.com/doi/10.1002/lt.500010208
Wiley
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