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Effect of taxifolin glycoside on atopic dermatitis-like skin lesions in NC/Nga mice

Phytotherapy Research, ISSN: 0951-418X, Vol: 24, Issue: 7, Page: 1071-1077
2010
  • 42
    Citations
  • 0
    Usage
  • 25
    Captures
  • 1
    Mentions
  • 0
    Social Media
Metric Options:   Counts1 Year3 Year

Metrics Details

  • Citations
    42
  • Captures
    25
  • Mentions
    1
    • References
      1
      • Wikipedia
        1

Article Description

Increased levels of eosinphils, IgE, IL-4, 5, and 13 and pro-inflammatory factors (COX-2, iNOS) are observed in patients with atopic dermatitis (AD). Taxifolin 3-O-β-D-glucopyranoside (TAX) from the roots of Rhododendron mucronulatum (RM) was examined to determine whether its immunomodulatory effect was applicable for treating atopic dermatitis. A total of 7 groups of NC/Nga mice with AD were treated by topical application or intraperitoneal injection of TAX for 4 weeks. Follow-up evaluations were done to assess the changes in clinical observations, eosinophil counts, and levels of IgE, cytokines, COX-2 and iNOS. In the clinical observation during the experimental period, TAX treatment significantly reduced the severity of AD-like lesions induced in NC/Nga mice. Eosinophil and IgE levels decreased after treatment of the animals with TAX. TAX may thus be associated with improvement of eosinophil-related allergic diseases. The expression of cytokines (IL-4, 5 and 13) was significantly inhibited in the TAX-treated group, suggesting that TAX might play an immunoregulatory role associated with AD. In RT-PCR, iNOS and COX-2 expression levels were reduced in the TAX-treated group. In western blotting, the expression levels of iNOS and COX-2 were also reduced in the TAX-treated group. These findings suggest that TAX is effective for the treatment of AD by preventing the production of inflammatory cytokines and by reducing skin inflammation. Copyright © 2009 John Wiley & Sons, Ltd.

Bibliographic Details

Ahn, Ji Young; Choi, Sun Eun; Jeong, Mi Sook; Park, Kwan Hee; Moon, Nam Ju; Joo, Seong Soo; Lee, Chung Soo; Choi, Young Wook; Li, Kapsok; Lee, Mi-Kyung; Lee, Min Won; Seo, Seong Jun

Wiley

Pharmacology, Toxicology and Pharmaceutics

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