Concise review: Progress and challenges in using human stem cells for biological and therapeutics discovery: Neuropsychiatric disorders
Stem Cells, ISSN: 1549-4918, Vol: 34, Issue: 3, Page: 523-536
2016
- 22Citations
- 119Captures
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Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
Citation Benchmarking is provided by Scopus and SciVal and is different from the metrics context provided by PlumX Metrics.
Metrics Details
- Citations22
- Citation Indexes20
- 20
- CrossRef17
- Policy Citations2
- 2
- Captures119
- Readers119
- 119
Review Description
In facing the daunting challenge of using human embryonic and induced pluripotent stem cells to study complex neural circuit disorders such as schizophrenia, mood and anxiety disorders, and autism spectrum disorders, a 2012 National Institute of Mental Health workshop produced a set of recommendations to advance basic research and engage industry in cell-based studies of neuropsychiatric disorders. This review describes progress in meeting these recommendations, including the development of novel tools, strides in recapitulating relevant cell and tissue types, insights into the genetic basis of these disorders that permit integration of risk-associated gene regulatory networks with cell/circuit phenotypes, and promising findings of patient-control differences using cell-based assays. However, numerous challenges are still being addressed, requiring further technological development, approaches to resolve disease heterogeneity, and collaborative structures for investigators of different disciplines. Additionally, since data obtained so far is on small sample sizes, replication in larger sample sets is needed. A number of individual success stories point to a path forward in developing assays to translate discovery science to therapeutics development.
Bibliographic Details
http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84958206316&origin=inward; http://dx.doi.org/10.1002/stem.2295; http://www.ncbi.nlm.nih.gov/pubmed/26840228; https://academic.oup.com/stmcls/article/34/3/523-536/6407558; http://doi.wiley.com/10.1002/stem.2295; http://onlinelibrary.wiley.com/doi/10.1002/stem.2295/abstract
Oxford University Press (OUP)
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