Effect of Vascular Endothelial Growth Factor on Nitric Oxide Production by Cultured Rat Mesangial Cells
Biochemical and Biophysical Research Communications, ISSN: 0006-291X, Vol: 245, Issue: 2, Page: 443-446
1998
- 19Citations
- 12Captures
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Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
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Metrics Details
- Citations19
- Citation Indexes19
- 19
- CrossRef15
- Captures12
- Readers12
- 12
Article Description
Vascular endothelial growth factor (VEGF) stimulates nitric oxide (NO) production by endothelial cells in vitro and in vivo. However, the impact of VEGF on inducible nitric oxide synthase (iNOS) activity and NO synthesis in cultured mesangial cells is not known. Therefore, we measured nitrite accumulation in cytokine-stimulated, rat mesangial cells (RMC) in response to graded concentrations of VEGF. Addition of VEGF (10-50 ng/ml) did not alter RMC viability or NO production in either normal (5.6 mM) or high (33.3 mM) glucose conditions. Exposure of RMC to VEGF did not modify the effects of L-arginine (20 mM) or L-NAME (1 mM) on nitrite accumulation in normal or high glucose media. The steady state abundance of iNOS mRNA and the cytosolic content of iNOS protein were unaffected by addition of VEGF. Cultured RMC expressed the high-affinity tyrosine kinase VEGF receptors, flt and flk /KDR, and the levels were not modulated by incubation in normal or high glucose media. We conclude that VEGF does not regulate proliferation or NO production in cultured RMC. These findings suggest that disturbances in the normal interaction between VEGF and NO are not involved in the pathogenesis of abnormal mesangial cell structure or function in diabetic nephropathy.
Bibliographic Details
http://www.sciencedirect.com/science/article/pii/S0006291X98984546; http://dx.doi.org/10.1006/bbrc.1998.8454; http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=0032540157&origin=inward; http://www.ncbi.nlm.nih.gov/pubmed/9571172; https://linkinghub.elsevier.com/retrieve/pii/S0006291X98984546; https://dx.doi.org/10.1006/bbrc.1998.8454
Elsevier BV
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