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The Functional Unit of Na,K-ATPase Is a Monomeric αβ Protomer

Biochemical and Biophysical Research Communications, ISSN: 0006-291X, Vol: 280, Issue: 5, Page: 1364-1366
2001
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Article Description

The ouabain-resistant and ouabain-sensitive α-subunit cRNAs in various molar ratios were injected into Xenopus oocytes together with cRNA for the β-subunit. The ouabain-resistant ATPase activity, as well as ouabain-resistant Rb + uptake, of the injected oocytes increased linearly with increasing the amount of cRNA for the ouabain-resistant α-subunit. When a functionless mutant was used instead of the ouabain-sensitive α-subunit, similar results were obtained in ATPase activity and Rb + uptake. These results indicate that a monomeric αβ protomer is a functional unit of membrane-bound Na,K-ATPase, even if the enzyme exists structurally as a diprotomer or higher oligomers in membranes.

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