Effects of Platelet-Activating Factor, Tumor Necrosis Factor, and Interleukin-1α on the Expression of Apolipoprotein M in HepG2 Cells
Biochemical and Biophysical Research Communications, ISSN: 0006-291X, Vol: 292, Issue: 4, Page: 944-950
2002
- 49Citations
- 11Captures
- 1Mentions
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Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
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Metrics Details
- Citations49
- Citation Indexes49
- 49
- CrossRef34
- Captures11
- Readers11
- 11
- Mentions1
- References1
- Wikipedia1
Article Description
Apolipoprotein M (apoM) is a recently discovered human apolipoprotein predominantly present in high-density lipoprotein (HDL) in plasma, exclusively expressed in liver and in kidney. The function of apoM is yet unknown. The human apoM gene is located in the major histocompatibility complex class III region on chromosome 6. Because many genes located in this region are related to the immune response, we have investigated whether apoM might also be involved in the host inflammatory response. In this study we examined effects of the platelet-activating factor (PAF), tumor necrosis factor (TNF-α), and interleukin-1α (IL-1α) on apoM expression in a hepatoblastoma cell line, HepG2 cells. PAF significantly enhanced the apoM mRNA levels and the secretion of apoM in HepG2 cell cultures. The enhancement of apoM secretion is seen at a low concentration of PAF (2 ng/ml), whereas a high concentration of PAF increases both the apoM mRNA levels and apoM secretion. Neither TNF-α nor IL-1α influenced apoM mRNA level and secretion. Furthermore, Lexipafant, a PAF-receptor (PAF-R) antagonist significantly suppressed the mRNA level and the secretion of apoM in HepG2 cells in a dose-dependent manner. Neither PAF nor Lexipafant influenced the mRNA levels and the secretion of apoA-I, apoB and apoE in HepG2 cells, indicating that the effects of PAF or Lexipafant on the apoM production on hepatic cells are selective for apoM. The cellular mechanism of the effects of PAF or Lexipafant on apoM metabolism requires further investigations.
Bibliographic Details
http://www.sciencedirect.com/science/article/pii/S0006291X02967550; http://dx.doi.org/10.1006/bbrc.2002.6755; http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=0036293085&origin=inward; http://www.ncbi.nlm.nih.gov/pubmed/11944906; https://linkinghub.elsevier.com/retrieve/pii/S0006291X02967550; https://dx.doi.org/10.1006/bbrc.2002.6755
Elsevier BV
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