Analysis of Leukocytes Recruited to the Pancreas by Diabetogenic T Cell Clones
Cellular Immunology, ISSN: 0008-8749, Vol: 189, Issue: 2, Page: 92-98
1998
- 17Citations
- 11Captures
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Metrics Details
- Citations17
- Citation Indexes17
- CrossRef17
- 16
- Captures11
- Readers11
- 11
Article Description
To investigate host leukocytes recruited to the pancreas by diabetogenic T cells, we administered islet-specific CD4 + T cell clones to 2-week-old nonobese diabetic (NOD) mice and examined the resulting pancreatic infiltrate by flow cytometry. Two different Vβ4 + CD4 + T cell clones, BDC 2.5 and BDC 6.9, were found to recruit a heterogeneous T cell population as determined by staining with a panel of anti-TCR Vβ monoclonal antibodies. The majority of the diabetes-initiating, Vβ4 + T cell clones migrated to the spleen whereas only 5–8% of the T cell population infiltrating the pancreas was Vβ4 +. Anti-IL-2 receptor staining indicated that fewer than 10% of the total population of infiltrating lymphocytes within the pancreas were in a highly activated state. We have further found that normal splenic T cells from the NOD mouse proliferate poorly to IL-2 in vitro, yet secrete IFN-γ in response to IL-2 stimulation. These results suggest that the recruited host T cells in our disease transfer system are not directly pathogenic but, rather, are responding to the small numbers of inflammatory T cell clones by providing cytokines that facilitate the disease process.
Bibliographic Details
http://www.sciencedirect.com/science/article/pii/S0008874998913776; http://dx.doi.org/10.1006/cimm.1998.1377; http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=0032213629&origin=inward; http://www.ncbi.nlm.nih.gov/pubmed/9790722; https://linkinghub.elsevier.com/retrieve/pii/S0008874998913776; https://dx.doi.org/10.1006/cimm.1998.1377
Elsevier BV
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