Bone Marrow-Derived Macrophages Express Functional CGRP Receptors and Respond to CGRP by Increasing Transcription of c-fos and IL-6 mRNA
Cellular Immunology, ISSN: 0008-8749, Vol: 209, Issue: 2, Page: 140-148
2001
- 44Citations
- 19Captures
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Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
Citation Benchmarking is provided by Scopus and SciVal and is different from the metrics context provided by PlumX Metrics.
Metrics Details
- Citations44
- Citation Indexes44
- 44
- CrossRef26
- Captures19
- Readers19
- 19
Article Description
Calcitonin gene-related peptide (CGRP) is a sensory neuropeptide with inflammatory and immunoregulatory properties. CGRP inhibits IL-7 responses by B cell precursors by direct and indirect mechanisms. We recently found that CGRP induces IL-6 and TNF-α in long-term bone marrow cultures and that IL-6 and TNF-α also inhibit IL-7 responses. Because these are heterogeneous cultures, it was not clear which cells produced IL-6 and TNF-α. To determine whether bone marrow-derived macrophages (BMDM) were the source, we did studies to determine whether BMDMs express mRNAs for CGRP receptors and whether CGRP induces c-fos, IL-6, and TNF-α mRNA. We found that BMDMs express mRNAs for CRLR and RAMP1, the minimal components for CGRP receptors. CGRP also stimulated dose- and time-dependent increases in c-fos and IL-6. In contrast, CGRP did not induce TNF-α in BMDMs. These results suggest that BMDMs are a source of CGRP-induced IL-6 in bone marrow.
Bibliographic Details
http://www.sciencedirect.com/science/article/pii/S0008874901917952; http://dx.doi.org/10.1006/cimm.2001.1795; http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=0035328556&origin=inward; http://www.ncbi.nlm.nih.gov/pubmed/11446746; https://linkinghub.elsevier.com/retrieve/pii/S0008874901917952; https://dx.doi.org/10.1006/cimm.2001.1795
Elsevier BV
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