The Effect of Space Flight on Monoclonal Antibody Synthesis in a Hybridoma Mouse Cell Line
Experimental Cell Research, ISSN: 0014-4827, Vol: 230, Issue: 2, Page: 411-414
1997
- 6Citations
- 5Captures
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Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
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Metrics Details
- Citations6
- Citation Indexes6
- CrossRef3
- Captures5
- Readers5
Article Description
The hybridoma cell line, 3G10G5, producing a monoclonal antibody to the major capsid protein VP1 from the avian polyomavirus budgerigar fledgling disease virus, was produced from a Balb/C mouse. This cell line was used to test the effects of microgravity on cellular processes, specifically protein synthesis. A time course study utilizing incorporation of [ 35 S]methionine into newly synthesized monoclonal antibody was performed on STS-77. After 5.5 days, it was observed that cell counts for the samples exposed to microgravity were lower than those of ground-based samples. However, radiolabel incorporation of the synthesized monoclonal antibody was similar in both orbiter and ground control samples. Overall, microgravity does not seem to have an effect on this cell line's ability to synthesize IgG protein.
Bibliographic Details
http://www.sciencedirect.com/science/article/pii/S001448279693445X; http://dx.doi.org/10.1006/excr.1996.3445; http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=0031079638&origin=inward; http://www.ncbi.nlm.nih.gov/pubmed/9024803; https://linkinghub.elsevier.com/retrieve/pii/S001448279693445X; https://dx.doi.org/10.1006/excr.1996.3445
Elsevier BV
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