Promiscuous Peptide Recognition of an Autoreactive CD8 + T-Cell Clone is Responsible for Autoimmune Intestinal Pathology
Journal of Autoimmunity, ISSN: 0896-8411, Vol: 18, Issue: 4, Page: 281-287
2002
- 10Citations
- 6Captures
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Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
Citation Benchmarking is provided by Scopus and SciVal and is different from the metrics context provided by PlumX Metrics.
Metrics Details
- Citations10
- Citation Indexes10
- 10
- CrossRef7
- Captures6
- Readers6
Article Description
We have recently described a CD8 + T-cell clone recognizing defined epitopes of both mycobacterial and murine hsp60 that are not sequence homologues. Adoptive transfer of this T-cell clone into T-cell deficient mice induced an autoimmune intestinal pathology. TCR analysis revealed the productive in frame rearrangement of two TCRa genes in this clone. Expression of two different TCR α chains by one T cell (dual TCR) is discussed as a potential mechanism underlying T-cell mediated autoimmunity. Here we addressed the question of whether hsp60 crossrecognition of self and non-self origin is directly linked to the surface expression of two TCRs by the same cell. Consequently, the potentially dual TCR of the hsp60 reactive T-cell clone was dissected into two single TCRs by double retroviral transduction of TCR deficient cell lines. Our data show that only one of the two TCR α/β combinations formed a functional cell surface TCR and that post-translational allelic exclusion of the second α chain was achieved by the inability to pair with the TCR β chain. Thus a single TCR is not only sufficient for crossrecognition with peptides that share minimal sequence homology, moreover this promiscuous TCR reactivity accounts also for immunopathology as recently shown.
Bibliographic Details
http://www.sciencedirect.com/science/article/pii/S0896841102905925; http://dx.doi.org/10.1006/jaut.2002.0592; http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=0036592059&origin=inward; http://www.ncbi.nlm.nih.gov/pubmed/12144809; https://linkinghub.elsevier.com/retrieve/pii/S0896841102905925; https://dx.doi.org/10.1006/jaut.2002.0592
Elsevier BV
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