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Participation of Intracellular Ca 2+ /Calmodulin and Protein Kinase(s) in the Pathway of Apoptosis Induced by a Drosophila Cell Death Gene, reaper

Molecular Cell Biology Research Communications, ISSN: 1522-4724, Vol: 4, Issue: 5, Page: 307-312
2001
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Article Description

To elucidate the apoptotic signaling pathway, we have generated a cell culture model: S2 cells stably transfected with a Drosophila cell death gene, reaper ( rpr ). Following rpr overexpression, caspase activation-mediated apoptotic cell death was induced in the cells. Apoptosis triggered by rpr required intracellular Ca 2+ ions and calmodulin. Furthermore, protein kinase inhibitors H-7 (a PKC, PKA, PKG, MLCK, and CKI inhibitor), calphostin C (a PKC inhibitor), or H-89 (a PKA and PKG inhibitor) completely blocked apoptosis induced by rpr, suggesting that some kind of serine/threonine protein kinase(s) act upstream of caspase in apoptotic pathway induced by rpr in S2 cells.

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