Bioelectric Toxicity Caused by Chlorpromazine in Human Lung Epithelial Cells
Toxicology and Applied Pharmacology, ISSN: 0041-008X, Vol: 183, Issue: 3, Page: 198-206
2002
- 11Citations
- 4Captures
Metric Options: CountsSelecting the 1-year or 3-year option will change the metrics count to percentiles, illustrating how an article or review compares to other articles or reviews within the selected time period in the same journal. Selecting the 1-year option compares the metrics against other articles/reviews that were also published in the same calendar year. Selecting the 3-year option compares the metrics against other articles/reviews that were also published in the same calendar year plus the two years prior.
Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
Citation Benchmarking is provided by Scopus and SciVal and is different from the metrics context provided by PlumX Metrics.
Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
Citation Benchmarking is provided by Scopus and SciVal and is different from the metrics context provided by PlumX Metrics.
Metrics Details
- Citations11
- Citation Indexes11
- CrossRef11
- 11
- Captures4
- Readers4
Article Description
Endogeneous and exogeneous amine-containing substances possess pneumophilic properties. Among them, tricyclic amphiphilic amine drugs like neuroleptics intensively accumulate in the lung cell membrane and occasionally cause severe respiratory disorders. In the present study, we examined the bioelectric toxicity of chlorpromazine (CPZ), a commonly used neuroleptic, in human lung epithelial cells. CPZ concentration-dependently inhibited the isoproterenol (ISO)-generated short-circuit current ( I sc ) sensitive to a nonselective K + channel blocker, clotrimazole (30 μM), but insensitive to a selective Ca 2+ -activated K + (K Ca ) channel blocker, charybdotoxin (ChTx, 100 nM). The effects of apical CPZ on the ISO-induced responses were greater than those of basolateral CPZ. Forskolin- and 8-bromo-cyclic AMP-induced I sc were partially prevented by CPZ. Nystatin permeabilization of the monolayers revealed that CPZ attenuated the basolateral K + current elicited by ISO more than that elicited by forskolin and that the apical Cl − current elicited by forskolin was instead potentiated by CPZ, although it inhibited the ISO-induced Cl − current. 1-Ethyl-2-benzimdazolinone (1-EBIO, a K Ca channel opener, 500 μM)- and ionomycin (Ca 2+ ionophore, 1 μM)-evoked Cl − secretions were also sensitive to CPZ. These results indicate that CPZ inhibits transepithelial Cl − transport, affecting at least two different targets: the β-adrenergic receptor and the basolateral K + channels (especially the K Ca channel). Electrostatic interactions at the inner surface of the membrane between the protonated amines of CPZ and negatively charged portions of the plasma membrane may be involved in the mechanisms.
Bibliographic Details
http://www.sciencedirect.com/science/article/pii/S0041008X0299486X; http://dx.doi.org/10.1006/taap.2002.9486; http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=0036396864&origin=inward; http://www.ncbi.nlm.nih.gov/pubmed/12383711; https://linkinghub.elsevier.com/retrieve/pii/S0041008X0299486X; https://dx.doi.org/10.1006/taap.2002.9486
Elsevier BV
Provide Feedback
Have ideas for a new metric? Would you like to see something else here?Let us know