K-recombination haplotype inference in pedigrees

Haplotyping under the Mendelian law of inheritance on pedigree genotype data is studied. Because genetic recombinations are rare, research has focused on Minimum Recombination Haplotype Inference (MRHI), i.e. finding the haplotype configuration consistent with the genotype data having the minimum number of recombinations. We focus here on the more realistic k-MRHI, which has the additional constraint that the number of recombinations on each parent-offspring pair is at most k. Although k-MRHI is NP-hard even for k = 1, we give an algorithm to solve k-MRHI efficiently by dynamic programming in 0(nm2) time on pedigrees with n nodes and at most m heterozygous loci in each node. Experiments on real and simulated data show that, in most cases, our algorithm gives the same haplotyping results but runs much faster than other popular algorithms. © Springer-Verlag Berlin Heidelberg 2005.