Improving solubility via structural modification
Topics in Medicinal Chemistry, ISSN: 1862-247X, Vol: 9, Page: 69-106
2014
- 10Citations
- 23Captures
Metric Options: CountsSelecting the 1-year or 3-year option will change the metrics count to percentiles, illustrating how an article or review compares to other articles or reviews within the selected time period in the same journal. Selecting the 1-year option compares the metrics against other articles/reviews that were also published in the same calendar year. Selecting the 3-year option compares the metrics against other articles/reviews that were also published in the same calendar year plus the two years prior.
Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
Citation Benchmarking is provided by Scopus and SciVal and is different from the metrics context provided by PlumX Metrics.
Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
Citation Benchmarking is provided by Scopus and SciVal and is different from the metrics context provided by PlumX Metrics.
Book Chapter Description
The examples and discussion presented in this review are intended to serve as resource for medicinal chemists engaged in the task of optimizing drug physical properties. A discussion of the factors governing aqueous solubility is presented followed by specific examples drawn from the recent literature. According to the general solubility equation (GSE), the factors involved in the solubility of a compound are represented by logP and melting point. Improved solubility can be accomplished by reducing logP or melting point by increasing polarity or disrupting intermolecular interactions in the solid state. Tactics for increasing polarity include introducing a solubilizing appendage onto the drug or modifying the template or attached substituents. The melting point of a compound can be lowered by disrupting specific intermolecular interactions or changing the topology or shape of the molecule.
Bibliographic Details
Springer Science and Business Media LLC
Provide Feedback
Have ideas for a new metric? Would you like to see something else here?Let us know