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History of research on nicotinic and muscarinic cholinergic receptors

Exploring the Vertebrate Central Cholinergic Nervous System, Page: 151-162
2007
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Book Chapter Description

The story of receptors is bound with the history of the recognition of chemical transmission at the periphery and in the central nervous system (CNS). In turn, this recognition is based on the progress in the description of the anatomy of the peripheral and central nervous systems. This progress was described in detail several times (see, for example, Brazier, 1959; Karczmar, 1967, 1986; Pick, 1970); at this time, it suffi ces to list the main steps of the early history of this progress and the principal authors who were involved (Table 4-1). As shown in the table, by the 18th century the main characteristics of the central, autonomic, and peripheral motor systems were laid down; in fact, even 250 years earlier the great da Vinci had rendered in his fi gures with much precision and few errors the details of the nervous systems (and other tissues).

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