Identification of Pan-Assay INterference compoundS (PAINS) Using an MD-Based Protocol
Methods in Molecular Biology, ISSN: 1940-6029, Vol: 2315, Page: 263-271
2021
- 6Citations
- 19Captures
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Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
Citation Benchmarking is provided by Scopus and SciVal and is different from the metrics context provided by PlumX Metrics.
Metrics Details
- Citations6
- Citation Indexes6
- Captures19
- Readers19
- 19
Book Chapter Description
Pan-assay interference compounds (PAINS) are promiscuous molecules with multiple behaviors that interfere with assay readouts. Membrane PAINS are a subset of these compounds that influence the function of membrane proteins by nonspecifically perturbing the lipid membranes that surround them. Here, we describe a computational protocol to identify potential membrane PAINS molecules by calculating the effect that a given compound has on the bilayer deformation propensity.
Bibliographic Details
http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85111637145&origin=inward; http://dx.doi.org/10.1007/978-1-0716-1468-6_15; http://www.ncbi.nlm.nih.gov/pubmed/34302681; https://link.springer.com/10.1007/978-1-0716-1468-6_15; https://dx.doi.org/10.1007/978-1-0716-1468-6_15; https://link.springer.com/protocol/10.1007/978-1-0716-1468-6_15
Springer Science and Business Media LLC
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