Large-Scale Production of Kidney Organoids from Human Pluripotent Stem Cells
Methods in Molecular Biology, ISSN: 1940-6029, Vol: 2664, Page: 69-83
2023
- 1Citations
- 10Captures
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Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
Citation Benchmarking is provided by Scopus and SciVal and is different from the metrics context provided by PlumX Metrics.
Metrics Details
- Citations1
- Citation Indexes1
- Captures10
- Readers10
- 10
Book Chapter Description
Kidney organoids differentiated from human pluripotent stem cells (hPSC) have advanced the study of kidney diseases by providing an in vitro system that outperforms traditional monolayer cell culture and complements animal models. This chapter describes a simple two-stage protocol that generates kidney organoids in suspension culture in less than 2 weeks. In the first stage, hPSC colonies are differentiated into nephrogenic mesoderm. In the second stage of the protocol, renal cell lineages develop and self-organize into kidney organoids that contain fetal-like nephrons with proximal and distal tubule segmentation. A single assay generates up to 1000 organoids, thereby providing a rapid and cost-efficient method for the bulk production of human kidney tissue. Applications include the study of fetal kidney development, genetic disease modelling, nephrotoxicity screening, and drug development.
Bibliographic Details
http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85164201271&origin=inward; http://dx.doi.org/10.1007/978-1-0716-3179-9_6; http://www.ncbi.nlm.nih.gov/pubmed/37423983; https://link.springer.com/10.1007/978-1-0716-3179-9_6; https://dx.doi.org/10.1007/978-1-0716-3179-9_6; https://link.springer.com/protocol/10.1007/978-1-0716-3179-9_6
Springer Science and Business Media LLC
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