Scale-Up of Phytosterols Bioconversion into Androstenedione
Methods in Molecular Biology, ISSN: 1940-6029, Vol: 2704, Page: 231-243
2023
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Book Chapter Description
Phytosterols, coming as a by-product of vegetable oils or wood pulp, contain the cyclopentanoperhydrophenanthrene nucleus and can be bioconverted into steroid intermediates by removing the C17 side chain. This chapter shows the scale-up, from flask to bioreactor, of phytosterols bioconversion into 4-androstene-3,17-dione (androstenedione; AD) using Mycolicibacterium neoaurum B-3805. Due to the fact that phytosterols and AD are nearly insoluble in water, two-phase systems and the use of chemically modified cyclodextrins have been described as methods to solve it. Here, we use a water–oil two-phase system that allows the bioconversion of up to 20 g/L of phytosterols into AD in 5 L and 20 L bioreactors.
Bibliographic Details
http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85168959022&origin=inward; http://dx.doi.org/10.1007/978-1-0716-3385-4_14; http://www.ncbi.nlm.nih.gov/pubmed/37642848; https://link.springer.com/10.1007/978-1-0716-3385-4_14; https://dx.doi.org/10.1007/978-1-0716-3385-4_14; https://link.springer.com/protocol/10.1007/978-1-0716-3385-4_14
Springer Science and Business Media LLC
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