Bisretinoids of RPE lipofuscin: Trigger for complement activation in age-related macular degeneration
Advances in Experimental Medicine and Biology, ISSN: 0065-2598, Vol: 703, Page: 63-74
2010
- 57Citations
- 32Captures
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Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
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Metrics Details
- Citations57
- Citation Indexes57
- 57
- CrossRef41
- Captures32
- Readers32
- 32
Book Chapter Description
Genetic association studies and investigations of the constituents of subretinal deposits (drusen) have implicated complement dysregulation as one factor predisposing individuals to increased risk of age-related macular degeneration (AMD). Here we review evidence that molecular fragments released by photooxidation of the bisretinoids of retinal pigment epithelial lipofuscin, can activate complement. Complement activation by this mechanism is dependent on the alternative pathway. The diretinal conjugates comprising RPE lipofuscin accumulate in the cells throughout the lifetime of an individual. As such, these photooxidative processes, in a setting of complement dysregulation could contribute to chronic inflammation underlying AMD pathogenesis. © Springer Science+Business Media, LLC 2010.
Bibliographic Details
http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=79952117474&origin=inward; http://dx.doi.org/10.1007/978-1-4419-5635-4_5; http://www.ncbi.nlm.nih.gov/pubmed/20711707; http://link.springer.com/10.1007/978-1-4419-5635-4_5; https://dx.doi.org/10.1007/978-1-4419-5635-4_5; https://link.springer.com/chapter/10.1007/978-1-4419-5635-4_5; http://www.springerlink.com/index/10.1007/978-1-4419-5635-4_5; http://www.springerlink.com/index/pdf/10.1007/978-1-4419-5635-4_5
Springer Science and Business Media LLC
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