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Insights into the structural basis of rna recognition by star domain proteins

Advances in Experimental Medicine and Biology, ISSN: 0065-2598, Vol: 693, Page: 37-53
2010
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Book Chapter Description

STAR proteins regulate diverse cellular processes and control numerous Developmentalevents. Theyfunctionatthe post-transcriptional levelbyregulating the stability, sub-cellular distribution, alternative splicing, ortranslational efficiency of specific rnRNA targets. Significant effort has been expended to define the determinants of RNA recognition by STAR proteins, in hopes of identifying new mRNA targets that contribute their role in cellular metabolism and development. This work has lead tothe extensive biochemical characterization of the nucleotide sequence specificity of a handful of STAR proteins. In contrast, little structural information is avaJLable to aialyze the molecular basis of sequence specific RNA recognition by this protein family. This chapter reviews the relevant literature on STAR domain protein structure and provides insights into how these proteins discriminate between different RNA sequences. © 2010 Landes Bioscience and Springer Science-f-Business Media.

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