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Plasmablastic lymphoma

Cancers in People with HIV and AIDS: Progress and Challenges, Page: 223-234
2014
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Book Chapter Description

Plasmablastic lymphoma (PBL) is a rare, aggressive lymphoma that is mainly seen in the human immunodeficiency virus (HIV)-positive population. It is a mature large B-cell lymphoma exhibiting plasmablastic morphology and with terminal B-cell, namely plasma cell-like, differentiation. PBL has a tendency to occur in the oral cavity; however, extraoral involvement is not infrequently encountered. While PBL shares some overlapping morphologic and immunophenotypic features with other mature B-cell lymphomas, PBL is currently classified as a distinct entity in the 2008 World Health Organization (WHO) Classification Tumors of Haematopoietic and Lymphoid Tissues (Swerdlow et al., WHO classification of tumours of haematopoietic and lymphoid tissues; 2008).

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