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Recombinant expression and purification of "virus-like" bacterial encapsulin protein cages

Methods in molecular biology (Clifton, N.J.), ISSN: 1940-6029, Vol: 1252, Page: 61-67
2015
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Book Chapter Description

Ultracentrifugation, particularly the use of sucrose or cesium chloride density gradients, is a highly reliable and efficient technique for the purification of virus-like particles and protein cages. Since virus-like particles and protein cages have a unique size compared to cellular macromolecules and organelles, the rate of migration can be used as a tool for purification. Here we describe a detailed protocol for the purification of recently discovered virus-like assemblies called bacterial encapsulins from Thermotoga maritima and Brevibacterium linens.

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