Studying the functions of TGF-β signaling in the ovary
Methods in Molecular Biology, ISSN: 1064-3745, Vol: 1344, Page: 301-311
2016
- 11Citations
- 7Captures
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Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
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Metrics Details
- Citations11
- Citation Indexes11
- 11
- CrossRef8
- Captures7
- Readers7
Book Chapter Description
In mammals, ovulation is a multistep physiological process that includes preovulatory follicle growth, oocyte meiotic maturation, cumulus-oocyte complex (COC) expansion, follicle rupture, and luteinization. TGF-β signaling pathway has multiple functions in mammalian ovary, as its complexity in ovarian function has been demonstrated by mouse models with knockouts of TGF-β receptors and SMADs. We describe the protocol that we use to study functions of TGF-β signaling pathway in follicle development and ovulation. Because total knockout of TGF-β pathway components often causes embryonic lethality, which prevents further investigation of these genes in ovarian functions, people have generated ovarian cell type-specific knockout mouse strains for TGF-β signaling pathway genes. These mouse models are also described.
Bibliographic Details
http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84946593309&origin=inward; http://dx.doi.org/10.1007/978-1-4939-2966-5_19; http://www.ncbi.nlm.nih.gov/pubmed/26520133; https://link.springer.com/10.1007/978-1-4939-2966-5_19; https://dx.doi.org/10.1007/978-1-4939-2966-5_19; https://link.springer.com/protocol/10.1007/978-1-4939-2966-5_19
Springer Science and Business Media LLC
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