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Novel Electrochemical Biosensor for Apoptosis Evaluation

Methods in Pharmacology and Toxicology, ISSN: 1940-6053, Page: 179-191
2016
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Book Chapter Description

Apoptosis evaluation is one of the most important tasks of toxicology. By using a peptide as the recognition element, and assembling apoptotic cells on a solid surface, we have established a novel electrochemical method for the detection of apoptosis levels. Such a peptide-based electrochemical biosensor is simple, cost-effective, convenient, and sensitive. Since the results obtained are well in line with other standard methods, this method holds a great potential towards the analysis of apoptosis and its applications. In this chapter, we introduce a general overview of this technical approach for detecting apoptotic cells. We discuss its advantages over the ordinary methods. We also provide practical guidelines for designing studies, and summarize the step-by-step protocols used in our lab for sample preparation, electrode modification, and accurate electrochemical quantification of apoptotic cells.

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