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Aberrant immunological synapses driven by leukemic antigen-presenting cells

Methods in Molecular Biology, ISSN: 1064-3745, Vol: 1584, Page: 533-544
2017
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Book Chapter Description

Aberrant immune synapse formation between antigen-presenting and immune effector cells is a central mediator of immune dysfunction and can be observed across several haematologic malignancies. Here, we describe the cell preparation, conjugation and immune synapse quantification of B and T cells obtained from patients with leukaemia and the adaptions required when using cells from murine models of disease.

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