Microdissection of Alzheimer brain tissue for the determination of focal manganese accumulation
Neuromethods, ISSN: 1940-6045, Vol: 124, Page: 109-118
2017
- 1Citations
- 8Captures
Metric Options: CountsSelecting the 1-year or 3-year option will change the metrics count to percentiles, illustrating how an article or review compares to other articles or reviews within the selected time period in the same journal. Selecting the 1-year option compares the metrics against other articles/reviews that were also published in the same calendar year. Selecting the 3-year option compares the metrics against other articles/reviews that were also published in the same calendar year plus the two years prior.
Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
Citation Benchmarking is provided by Scopus and SciVal and is different from the metrics context provided by PlumX Metrics.
Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
Citation Benchmarking is provided by Scopus and SciVal and is different from the metrics context provided by PlumX Metrics.
Book Chapter Description
This protocol utilizes immunohistochemistry to assist the laser microdissection and capture of tissue regions of interest isolated from slide-mounted sections for subsequent analysis of metal content. When used in conjunction with inductively coupled plasma mass spectrometry it becomes a powerful method to determine pathogenetically related shifts in the concentration of various cortical transition metals. Key advantages of this approach include being able to isolate target and directly adjacent brain regions for easy comparative analysis free from potential metal contamination as can occur during surgically based isolation of tissue elements. In this chapter, I present a well-optimized and validated method to achieve contamination-free detection of microscopically defined regions of manganese concentration in Alzheimer’s disease brain tissue with an emphasis on amyloid plaque analysis.
Bibliographic Details
http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85017203347&origin=inward; http://dx.doi.org/10.1007/978-1-4939-6918-0_6; http://link.springer.com/10.1007/978-1-4939-6918-0_6; http://link.springer.com/content/pdf/10.1007/978-1-4939-6918-0_6; https://doi.org/10.1007%2F978-1-4939-6918-0_6; https://dx.doi.org/10.1007/978-1-4939-6918-0_6; https://link.springer.com/protocol/10.1007/978-1-4939-6918-0_6
Springer Science and Business Media LLC
Provide Feedback
Have ideas for a new metric? Would you like to see something else here?Let us know