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NeuroaiDS: A review of gene expression in neurons, astrocytes, and oligodendrocytes

Global Virology II - HIV and NeuroAIDS, Page: 519-532
2017
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Book Chapter Description

Modern biotechnology techniques with focus on RNA and protein gene expression have fundamentally altered our view of the pathogenesis of neurological diseases, in general, and HIV-associated neurocognitive disorders (HAND), in particular. Extensive analysis of gene expression enables scientists to assess the simultaneous expression modes of enormous groups of genes. The alterations in adjustment and expression modes of these genes in relation to pathophysiology of NeuroAIDS and HAND provide us with crucial clues into molecular mechanisms of development of AIDS invasion to and infection of human nervous system and how such a vast process affects different tissues within the peripheral immune system and the nervous system. The present chapter focuses on the latest findings in gene expression patterns during pathophysiology of HAND with emphasis on their potential application for treatment of these patients. Specifically, through this chapter we concentrate on the gene expression by the cells within the central nervous system (CNS), neurons, astrocytes, and oligodendrocytes during pathogenesis of HAND.

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