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Production of proteins for NMR studies using the wheat germ cell-free system.

Methods in molecular biology (Clifton, N.J.), ISSN: 1064-3745, Vol: 310, Page: 169-185
2005
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Book Chapter Description

This chapter describes protocols for preparing 15N-labeled proteins (ubiquitin is used as an example) using Escherichia coli cells (with purification) and the wheat germ cell-free system (without purification). A comparison of 1H-15N heteronuclear single-quantum coherence (HSQC) spectra of yeast ubiquitin prepared using each method indicates that this wheat germ cell-free system may be used for rapid nuclear magnetic resonance analyses of proteins without purification.

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