SAGE programs: model-free linkage analysis for complex cardiovascular phenotypes.
Methods in molecular medicine, ISSN: 1543-1894, Vol: 128, Page: 61-89
2006
- 3Citations
- 6Captures
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Book Chapter Description
A complex disease trait refers to a phenotype that does not follow simple Mendelian segregation attributable to a single gene locus, but instead may be caused by multiple disease loci, their interactions, polygenic inheritance, and environmental effects. Most cardiovascular disorders are thought to have a polygenic basis with complex interactions with environmental factors. A gene that increases or decreases the risk to a complex cardiovascular disease (susceptibility gene) can now be mapped to a specific chromosomal region by model-free linkage analysis, and follow-up molecular genetic studies can identify the specific gene at the locus. This chapter describes a protocol for model-free linkage analysis of a complex trait, as implemented in the popular genetic analysis software-SAGE. In particular, the Haseman-Elston sib-pair regression method is introduced and implemented with examples to demonstrate how to identify susceptibility loci for complex traits.
Bibliographic Details
http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=38549099238&origin=inward; http://dx.doi.org/10.1007/978-1-59745-159-8_6; http://link.springer.com/10.1007/978-1-59745-159-8_6; http://link.springer.com/content/pdf/10.1007/978-1-59745-159-8_6.pdf; https://dx.doi.org/10.1007/978-1-59745-159-8_6; https://link.springer.com/protocol/10.1007/978-1-59745-159-8_6; http://www.springerlink.com/index/10.1007/978-1-59745-159-8_6; http://www.springerlink.com/index/pdf/10.1007/978-1-59745-159-8_6
Springer Science and Business Media LLC
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