Holy SNP, batman!
Methods in Pharmacology and Toxicology, ISSN: 1940-6053, Page: 207-227
2008
- 7Captures
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Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
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Metrics Details
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Book Chapter Description
The interaction between genetic variation and environment is widely acknowledged as the underlying explanation for differences in drug response among individuals, as well as the stratifying force behind disease phenotypes. When DNA variation is found to associate with a phenotype, the investigator's first inclination is to try to explain the finding. The SNP(s) identified (or others in LD) are generally thought to cause either a change in amino acid sequence that alters protein structure/function or a change in gene product expression that is due to altered affinity between cis - and trans -acting factors in the promoter. There is currently an underappreciation for the multifarious interactions that exist between SNPs and the cellular machinery and how this may impact drug response and disease genetics. The purpose of this chapter is to dispel the common view that so-called functional SNPs will be recognizable either by their ability to alter the sequences of cis -acting sites or by their ability to change the amino acid sequences of proteins. Other interactions of functional consequence will also be presented for consideration. © 2008 Humana Press, a part of Springer Science+Business Media, LLC.
Bibliographic Details
http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=78649433864&origin=inward; http://dx.doi.org/10.1007/978-1-59745-439-1_10; http://link.springer.com/10.1007/978-1-59745-439-1_10; http://link.springer.com/content/pdf/10.1007/978-1-59745-439-1_10.pdf; http://www.springerlink.com/index/10.1007/978-1-59745-439-1_10; http://www.springerlink.com/index/pdf/10.1007/978-1-59745-439-1_10; https://dx.doi.org/10.1007/978-1-59745-439-1_10; https://link.springer.com/protocol/10.1007/978-1-59745-439-1_10
Springer Science and Business Media LLC
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