Measurement of DNA damage in individual cells using the Single Cell Gel Electrophoresis (Comet) assay.
Methods in molecular biology (Clifton, N.J.), ISSN: 1940-6029, Vol: 731, Page: 309-20
2011
- 10Citations
- 14Captures
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Metrics Details
- Citations10
- Citation Indexes10
- CrossRef10
- Captures14
- Readers14
- 14
Book Chapter Description
The Single Cell Gel Electrophoresis (Comet) assay is a simple, versatile and sensitive method for measuring DNA damage in individual cells, allowing the determination of heterogeneity of response within a cell population. The basic alkaline technique described is for the determination of DNA strand break damage and its repair at a single cell level. Specific modifications to the method use a lower pH ('neutral' assay), or allow the measurement of DNA interstrand cross-links. It can be further adapted to, for example, study specific DNA repair mechanisms, be combined with fluorescent in situ hybridisation, or incorporate lesion specific enzymes.
Bibliographic Details
http://www.ncbi.nlm.nih.gov/pubmed/21516417; http://dx.doi.org/10.1007/978-1-61779-080-5_25; https://link.springer.com/10.1007/978-1-61779-080-5_25; https://dx.doi.org/10.1007/978-1-61779-080-5_25; https://link.springer.com/protocol/10.1007/978-1-61779-080-5_25; http://www.springerlink.com/index/10.1007/978-1-61779-080-5_25; http://www.springerlink.com/index/pdf/10.1007/978-1-61779-080-5_25
Springer Science and Business Media LLC
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