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Topology determination of untagged membrane proteins

Methods in Molecular Biology, ISSN: 1064-3745, Vol: 1033, Page: 121-130
2013
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Book Chapter Description

The topology of integral membrane proteins with a weak topological tendency can be influenced when fused to tags, such as these used for topological determination or protein purification. Here, we describe a technique for topology determination of an untagged membrane protein. This technique, optimized for bacterial cells, allows the visualization of the protein in the native environment and incorporates the substituted-cysteine accessibility method. © 2013 Springer Science+Business Media, LLC.

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