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Expression and purification of recombinant antibody formats and antibody fusion proteins

Methods in Molecular Biology, ISSN: 1064-3745, Vol: 1131, Page: 273-295
2014
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Book Chapter Description

In the laboratory-scale production of antibody fragments or antibody fusion proteins, it is often difficult to keep track on the most suitable affinity tags for protein purification from either prokaryotic or eukaryotic host systems. Here, we describe how such recombinant proteins derived from Escherichia coli lysates as well as HEK293 cell culture supernatants are purified by IMAC and by different affinity chromatography methods based on fusions to FLAG-tag, Strep-tag, and Fc domains. © 2014 Springer Science+Business Media, New York.

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