Clinical and Neuroimaging Aspects of Familial Frontotemporal Lobar Degeneration Associated with MAPT and GRN Mutations
Advances in Experimental Medicine and Biology, ISSN: 2214-8019, Vol: 1281, Page: 77-92
2021
- 6Citations
- 7Captures
- 1Mentions
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- Citations6
- Citation Indexes6
- Captures7
- Readers7
- Mentions1
- News Mentions1
- 1
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Clinical and Neuroimaging Aspects of Familial Frontotemporal Lobar Degeneration Associated with MAPT and GRN Mutations.
Adv Exp Med Biol. 2021;1281:77-92. Authors: Boeve BF, Rosen H PubMed: 33433870 Submit Comment
Book Chapter Description
Numerous kindreds with familial frontotemporal lobar degeneration have been linked to mutations in microtubule-associated protein tau (MAPT) or progranulin (GRN) genes. While there are many similarities in the clinical manifestations and associated neuroimaging findings, there are also distinct differences. In this review, we compare and contrast the demographic/inheritance characteristics, histopathology, pathophysiology, clinical aspects, and key neuroimaging findings between those with MAPT and GRN mutations.
Bibliographic Details
http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85099894463&origin=inward; http://dx.doi.org/10.1007/978-3-030-51140-1_6; http://www.ncbi.nlm.nih.gov/pubmed/33433870; http://link.springer.com/10.1007/978-3-030-51140-1_6; https://dx.doi.org/10.1007/978-3-030-51140-1_6; https://link.springer.com/chapter/10.1007/978-3-030-51140-1_6
Springer Science and Business Media LLC
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