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Nuclear Export of mRNAs with Disease Pathogenesis and Therapeutic Implications

RNA Technologies, ISSN: 2197-9758, Vol: 13, Page: 371-395
2022
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Book Chapter Description

In eukaryotes, RNA polymerase II genes are transcribed to mRNAs, processed in the nucleus, and then exported to the cytoplasm through the nuclear pore complex for translation to proteins. Thus, eukaryotic gene expression is regulated at multiple steps via coordinated actions of a large number of proteins in different cellular compartments. In this chapter, we describe how gene expression is controlled at the level of mRNA export from nucleus to the cytoplasm with implications for disease pathogenesis and therapeutic development.

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