Multi-Modality Imaging for Prediction of Tumor Control Following Radiotherapy

Multi-modality imaging techniques, such as hybrid systems combining positron emission tomography (PET) and magnetic resonance imaging (MRI) or computed tomography (CT), provide various possibilities to acquire quantitative imaging biomarkers of tumors. Several studies have shown the potential of such quantitative imaging biomarkers to predict tumor control following radiotherapy. In this chapter, an overview on technical requirements of multi-modality imaging systems, which need to be fulfilled to qualify potential biomarkers for response modeling, is given. Furthermore, examples of quantitative imaging biomarkers from different imaging modalities, which were shown in recent studies to be predictive for tumor control after radiotherapy, are discussed. The ultimate goal of training prediction models based on multi-modality imaging parameters is a potential future use of such models to steer personalized radiotherapy concepts using individualized prescriptions for, e.g., dose painting.