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Disordered Hemostasis and Renal Disorders

Pediatric Kidney Disease, Page: 877-901
2023
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Metric Options:   Counts1 Year3 Year

Book Chapter Description

Renal disorders can impact the balance of hemostasis and result in predispositions to either bleeding or thrombosis. This delicate balance is influenced by normal physiologic changes to coagulation, known as developmental hemostasis, that need to be taken into consideration when assessing and treating children with kidney diseases. This chapter reviews the main developmental hemostasis changes that occur during childhood. Furthermore, the two sides of hemostasis are then described in detail, including conditions associated with bleeding (uremic coagulopathy) and thromboses (nephrotic syndrome, renal vascular thromboses, renal transplantation, and hemolytic uremic syndrome). Treatment recommendations are provided based on best evidence and standards, with updated information on clinical guidelines and use of new oral anticoagulant agents.

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