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Gary M. Bokoch, the Rac-n-Rho Man: His Fascination with Rho-GTPases

NADPH Oxidases Revisited: From Function to Structure, Page: 123-132
2023
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Book Chapter Description

Dr. Gary Bokoch’s legacy (Fig. 8.1) continues in each of us who learned about RhoGTPases through his training, publications, collaborations, and presentations. His expertise on RhoGTPases provided the root for the branches of his studies into fields such as chemotaxis, the actin cytoskeleton, p-21 activated kinases, LIM kinase, and NADPH oxidases. A survey of his 217 publications from his graduate work to his final days as professor clearly showed that the topic of neutrophils was special to him since that is how his successful scientific career began. From working on arachidonic metabolism in guinea pig neutrophils during graduate school, to identifying the Gialpha (Giα)-subunit while a post-doc in the laboratory of Nobel Laureate, Dr. Alfred Gilman, to discovering functions for RhoGTPases in NOX2 in neutrophils, Dr. Bokoch’s dedication to this field has taught us how to approach studies on signaling mechanisms applicable to many areas of science. I hope my presentation of Dr. Bokoch (Gary as I shall address him hereon) will paint a vivid picture of his journeys that led him to the path of NADPH Oxidases. As for the many other scientific paths on which he traveled, they would each require a separate chapter.

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