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Kallikrein 8-dependent and independent synaptic tagging and modulation of long-term potentiation: A quest for the associated signaling pathway(s)

Synaptic Tagging and Capture: From Synapses to Behavior: Second Edition, Page: 179-193
2024
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Book Chapter Description

Synaptic tagging is a plausible hypothesis to explain relational memory. However, why and how the tagged synapses can be distinguished from other nonactivated synapses has not yet been clarified. Early-phase long-term potentiation (E-LTP)-related signaling molecules and intracellular molecular trafficking for capturing these toward tagged synapses have been considered essential for the synaptic tagging apparatus. In this chapter, we describe a new mechanism of synaptic tagging that shares the same set of E-LTP induction mechanisms as above; that is, E-LTP-specific proteolysis by Kallikrein 8/neuropsin (KLK8), an extracellular serine protease, is involved in the KLK8-dependent form of synaptic and behavioral tagging.

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