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Solid drug nanoparticles

Fundamentals of Pharmaceutical Nanoscience, Page: 63-88
2024
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Book Chapter Description

Solid drug nanoparticles (SDNs) are formulations in which the drug presents as a sub-micron particle stabilised by surfactants, polymers or sugars. These formulations are prepared using scalable industrial processes and contain high levels of drug compared to excipient. They may be prepared by milling or other size reduction techniques or by self-assembly or nanoprecipitation methods. SDNs may be used to significantly improve oral bioavailability, or deliver hydrophobic drugs as a suspension via the intravenous or subcutaneous routes for a long-acting outcome. SDNs may also be used via the pulmonary route or for topical application to the skin or ocular surface tissues. Many approved formulations exist for clinical use, demonstrating their versatility.

Bibliographic Details

Catherine Unsworth; Alison C. Savage; Steve P. Rannard

Springer Science and Business Media LLC

Medicine; Pharmacology, Toxicology and Pharmaceutics; Health Professions; Chemistry; Engineering; Biochemistry, Genetics and Molecular Biology; Materials Science

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