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The Intestinal Neuro-immune Axis

Neuroimmune Diseases: From Cells to the Living Brain, Second Edition, Page: 419-461
2024
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Book Chapter Description

The functioning of the neuro-immune axis is a vital factor that contributes to the maintenance of the gut’s microbial homeostasis. It involves a complex network of communication between the gut microbiota, immune cells, and the nervous system. Through this communication, the axis can orchestrate the response of the immune system to pathogens. The various neuropeptides, immune mediators, and neurotransmitters that are involved in this network play a role in regulating the function of the immune system and the production of cytokines. The functioning of the axis has been linked to different gastrointestinal disorders. Understanding the role of the neuro-immune axis in the modulation of the immune response and the control of bacterial populations is very important in the development of effective gastrointestinal therapies. This review chapter aims to provide a comprehensive analysis of the current knowledge about the link between the intestinal neuro-immune axis and various gastrointestinal disorders.

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