Regulation of adaptive immunity in the elderly
Immunosenescence, Page: 1-23
2012
- 2Citations
- 5Captures
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Book Chapter Description
There is accumulating evidence that older individuals show a decline in cell-mediated immunity. This is evidenced by the increased susceptibility to infections and cancers and reduced effectiveness of vaccinations. In addition to this decline in immune competence, old individuals also show signs of immune dysregulation, such as increased incidence of autoimmunity and chronic inflammatory diseases. Numerous changes occur within the immune system as we age, including alterations to both innate and adaptive arms of the immune system. We discuss here the factors that might affect adaptive immunity in the elderly, with the emphasis on the mechanisms of immune regulation.
Bibliographic Details
http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84997284627&origin=inward; http://dx.doi.org/10.1007/978-3-0346-0219-8_1; http://link.springer.com/10.1007/978-3-0346-0219-8_1; http://www.springerlink.com/index/10.1007/978-3-0346-0219-8_1; http://www.springerlink.com/index/pdf/10.1007/978-3-0346-0219-8_1; https://dx.doi.org/10.1007/978-3-0346-0219-8_1; https://link.springer.com/chapter/10.1007/978-3-0346-0219-8_1
Springer Science and Business Media LLC
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