Proposed animal model of severe Parkinson's disease: Neonatal 6-hydroxydopamine lesion of dopaminergic innervation of striatum
Journal of Neural Transmission, Supplement, ISSN: 0303-6995, Issue: 70, Page: 277-279
2006
- 25Citations
- 2Usage
- 9Captures
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Metrics Details
- Citations25
- Citation Indexes25
- 25
- CrossRef9
- Usage2
- Abstract Views2
- Captures9
- Readers9
Conference Paper Description
Rats lesioned shortly after birth with 6-hydroxydopamine are posed as a near-ideal model of severe Parkinson's disease, because of the non-lethality of the procedure, near-total destruction of nigrostriatal dopaminergic fibers, near-total dopamine (DA)-denervation of striatum, reproducibility of effect, and relative absence of overt behavioral effects - there is no aphasia, no adipsia, and no change in motor activity. In vivo microdialysis findings reinforce the utility of the animal model, clearly demonstrating L-DOPA beneficial actions without an increase in hydroxyl radical production. © Springer-Verlag 2006.
Bibliographic Details
http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=33750357866&origin=inward; http://dx.doi.org/10.1007/978-3-211-45295-0_43; http://www.ncbi.nlm.nih.gov/pubmed/17017542; http://link.springer.com/10.1007/978-3-211-45295-0_43; https://dc.etsu.edu/etsu-works/18164; https://dc.etsu.edu/cgi/viewcontent.cgi?article=19430&context=etsu-works; http://www.springerlink.com/index/10.1007/978-3-211-45295-0_43; http://www.springerlink.com/index/pdf/10.1007/978-3-211-45295-0_43; https://dx.doi.org/10.1007/978-3-211-45295-0_43; https://link.springer.com/chapter/10.1007/978-3-211-45295-0_43
Springer Science and Business Media LLC
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