Isolation and characterization of stem cells from human central nervous system malignancies
Advances in Experimental Medicine and Biology, ISSN: 2214-8019, Vol: 853, Page: 33-47
2015
- 3Citations
- 11Captures
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Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
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Metrics Details
- Citations3
- Citation Indexes3
- CrossRef2
- Captures11
- Readers11
- 11
Book Chapter Description
Central Nervous System (CNS) tumors include some of the most invasive and lethal tumors in humans. The poor prognosis in patients with CNS tumors is ascribed to their invasive nature. After the description of a stem cell-like cohort in hematopoietic cancers, tumor stem cells (TSCs) have been isolated from a variety of solid tumors, including brain tumors. Further research has uncovered the crucial role these cells play in the initiation and propagation of brain tumors. More importantly, TSCs have also been shown to be relatively resistant to conventional cytotoxic therapeutics, which may also account for the alarmingly high rate of CNS tumor recurrence. In order to elucidate prospective therapeutic targets it is imperative to study these cells in detail and to accomplish this, we need to be able to reliably isolate and characterize these cells. This chapter will therefore, provide an overview of the methods used to isolate and characterize stem cells from human CNS malignancies.
Bibliographic Details
http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84928525135&origin=inward; http://dx.doi.org/10.1007/978-3-319-16537-0_3; http://www.ncbi.nlm.nih.gov/pubmed/25895706; https://link.springer.com/10.1007/978-3-319-16537-0_3; https://dx.doi.org/10.1007/978-3-319-16537-0_3; https://link.springer.com/chapter/10.1007/978-3-319-16537-0_3
Springer Science and Business Media LLC
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