Molecular pathogenesis of primary adrenal cushing’s syndrome
The Hypothalamic-Pituitary-Adrenal Axis in Health and Disease: Cushing's Syndrome and Beyond, Page: 67-92
2016
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Metric Options: CountsSelecting the 1-year or 3-year option will change the metrics count to percentiles, illustrating how an article or review compares to other articles or reviews within the selected time period in the same journal. Selecting the 1-year option compares the metrics against other articles/reviews that were also published in the same calendar year. Selecting the 3-year option compares the metrics against other articles/reviews that were also published in the same calendar year plus the two years prior.
Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
Citation Benchmarking is provided by Scopus and SciVal and is different from the metrics context provided by PlumX Metrics.
Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
Citation Benchmarking is provided by Scopus and SciVal and is different from the metrics context provided by PlumX Metrics.
Metrics Details
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Book Chapter Description
Recent advances in whole genome/exome sequencing have greatly accelerated our understanding of the molecular mechanisms of tumorigenesis in adrenocortical tumors and hyperplasia. Maintenance of hypercortisolism in primary adrenal Cushing’s syndrome despite the suppression of ACTH secretion by the pituitary results from germline or somatic mutations in a variety of genes as well as from aberrant expression and function of several hormone receptors. This review focuses on novel genetic alterations involved in the cAMP signaling pathway or in armadillo proteins such as ARMC5 and β-catenin as well as on autocrine/paracrine regulatory secretory loops responsible for the abnormal adrenal steroidogenesis in primary adrenal causes of Cushing’s syndrome.
Bibliographic Details
http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85029097816&origin=inward; http://dx.doi.org/10.1007/978-3-319-45950-9_4; http://link.springer.com/10.1007/978-3-319-45950-9_4; https://dx.doi.org/10.1007/978-3-319-45950-9_4; https://link.springer.com/chapter/10.1007/978-3-319-45950-9_4
Springer Science and Business Media LLC
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